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Neuromyelitis Optica Spectrum Disorder
Neuromyelitis Optica Spectrum Disorder Often Makes It More Difficult to Find, or Keep, a Job
A report of NMOSD patients in the US highlights the challenges they face in the workforce, as well as factors that would improve the experience of this patient population.
Are Patients With NMOSD and MS at Higher Risk of Fractures?
A study in South Korea found that patients with multiple sclerosis and neuromyelitis optica spectrum disorder have a high risk of fractures, particularly hip fractures. These patients should be assessed for fractures and preventive measures should be used to try to reduce this risk.
Use These Strategies for a Timely NMOSD Diagnosis
NMOSD is frequently misdiagnosed upon initial presentation, but early neuroimmunologist referral, MRI evaluation, and AQP4-IgG testing can help identify patients earlier to facilitate appropriate management.
How NMOSD and MS are Impacted by COVID-19 Infection and Vaccination
This retrospective, observational cohort study analyzed the risk of disease exacerbation in multiple sclerosis and neuromyelitis optica spectrum disorder following COVID-19 infection or COVID-19 vaccination.
NMOSD and MS May Boost the Risk of MI
A recent analysis found that MI risk was increased in patients with NMOSD and MS compared to the general population. The risk was elevated to a similar extent in patients with these disorders.
B-cell Repletion After Anti-CD20 Infusion: Are There Differences Between Races?
A new study looked at adult Black and White patients with a diagnosis of MS or NMOSD, with the goal of examining differences in B-cell reemergence after anti-CD20 infusions. Here’s what the experts found.
Neuromyelitis Optica Spectrum Disorder and the Effects of Pregnancy
Neuromyelitis optica spectrum disorder, a potentially damaging inflammatory condition of the nervous system, affects women of childbearing age. These investigators looked at the risks of relapse associated with pregnancy, identifying factors that may mitigate this threat.
Asymptomatic Radiographic Optic Nerve Lesions and NMOSD Attacks
The nature and prevalence of asymptomatic optic nerve enhancement in patients with NMOSD is poorly understood, limiting the usefulness of this criterion when studying NMOSD attacks. These investigators report on a new analysis that may change that.
In NMOSD, Could Inhibiting Complement C5a Help Reduce Pain?
Investigators recently found that complement C5a was elevated in patients with neuromyelitis optica spectrum disorder in remission compared with healthy controls, and in patients with pain compared with patients without pain.
Quantifying the Struggles of Patients with NMOSD
Symptom severity, depression, fatigue, and pain all affect quality of life in patients with neuromyelitis optica spectrum disorder, say the results of a new study, highlighting the importance of symptom burden awareness for early intervention.
Is This a Better Way to Screen for NMOSD?
A team of researchers at Massachusetts General Hospital believe they have identified a reliable, low-cost way to screen for neuromyelitis optica spectrum disorder (NMOSD).
Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder: New Clinical Distinctions
It isn’t always obvious what sets apart multiple sclerosis from neuromyelitis optica spectrum disorder, but an MRI-based examination of brain network and subnetwork topology by a team of South Korean investigators may help sharpen the clinical picture.
Chronic Pain and Depression in NMOSD: Underrecognized and Undertreated
A recent study demonstrated the need to address chronic pain and depression in AQP4 antibody seropositive neuromyelitis optica spectrum disorder.
NMOSD, Fatigue, and Thalamic Volume
This study examined brain subcortical structures and found that atrophy in the right thalamus correlated to fatigue severity, suggesting this could serve as a biomarker to help predict severity in patients with NMOSD.
NMO/NMOSD: New Learnings
A 2015 review on the incidence and prevalence of neuromyelitis optica/neuromyelitis optica spectrum disorder (NMO/NMOSD) triggered nearly two dozen additional studies. Recently, a global team of experts examined the types of data collected and provided an overview.
Monitoring Optic Nerve Lesion Length in Patients with Demyelinating Disease
For patients with acute optic neuritis, measuring early optic nerve lesion length may predict neuro-axonal loss and serve as a biomarker for chronic visual impairment in the future.
In Children with NMOSD: Against Long-Term Disability
Children with neuromyelitis optica spectrum disorder (NMOSD) need early assessment and active management with immunosuppressive therapy to allow them the best chance of delayed progression and limited disability.
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MOGAD: 5-Year Visual Outcomes After a Diagnosis of Optic Neuritis
A recent analysis suggests that patients with anti-myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) have better long-term visual outcomes than those with anti-aquaporin-4 (AQP4) antibody-positive neuromyelitis optica spectrum disorder (NMSOD), but similar to those with multiple sclerosis.
NMOSD: Subclinical Retinal Disease and Progression
A recent study evaluated whether silent, subclinical disease activity and progression occurred during NMOSD outside of NMOSD relapses, and determined whether there were consequential neurologic deficits due to this subclinical activity.
In NMOSD and MS, Macular Vessel Density Differs
Vascular change is a recognized component of the demyelinating diseases MS and NMOSD. This study found that the retinal capillary alterations in MS and NMOSD are distinct, however.
Q&A: Our (Very) Rapidly Evolving Understanding of NMOSD
A conversation with Mayo Clinic’s Eoin P. Flanagan, MB, BCh
NMOSD Tied to Insulin Resistance
New research into NMOSD, a rare, neurologic autoimmune disease, suggests an independent association between risk of NMOSD and insulin resistance. This may have implications for both the development of diabetes and the treatment of the underlying condition in NMOSD patients.
NMOSD and New Treatment Frontiers
In recent years, the U.S. Food and Drug Administration (FDA) has looked favorably on new therapies for neuromyelitis optica spectrum disorder (NMOSD). Here’s a review of what’s on the clinical horizon for this chronic condition.
NMOSD Biomarkers: Prognostic Value of Two Candidates
If diagnosed sooner than later, NMOSD can be managed successfully. But once in remission, treatment decisions become more difficult. Are there biomarkers that might indicate who will fare better (or worse) with treatment?